- Anticancer Targets: Molecular Regulation and Drug Resistance of Cancer Genes (癌症基因的分子調控與抗藥機轉)
- Anticancer Drugs: Molecular Mechanism and Cancer Therapy of Anticancer Drugs (抗癌藥物的分子機制和癌症治療)
- Anticancer Nanotechnology: Molecular Interaction and Biological Impact of Nanoparticulophagy (奈米自噬的分子作用及生物影響)
The Chao laboratory has contributed the roles of Survivin and EGFR in regulating tumor growth and drug resistance. We seek to translate insights in inhibiting cancer growth genes by novel compounds into improved therapies for malignant tumors. Our studies contributed nanodiamond, a carbon-based nanomaterial, on biocompatible evaluation, bio-labeling, drug delivery and biological impacts. Selective autophagy plays a pivotal role in the processing of foreign pathogens, cellular components, and damaged organelles to maintain homeostasis in human cells. Selective autophagy receptors contain an Ub-associated domain and an LC3-interacting region, which can recruit LC3-containing autophagosomes to ubiquitinated cargos into selective autophagy pathway. We found for the first time that ubiquitin-coated nanodiamonds bind to selective autophagy receptors (SQSTM1, OPTN and NDP52) for entry into the selective autophagy pathway. Our study provides novel insight that ubiquitin-coated nanoparticles bind to autophagy receptors for entry into the selective autophagy pathway, facilitating their delivery to lysosomes. We illustrate the biological impacts and pivotal roles of autophagy receptors in transportation and drug delivery by those nanomaterials. In recent years, we focus on the investigation of selective autophagy receptors in cancers and nanodrug delivery.